At the end of his career Derek Zoolander (Stiller), a clueless fashion model is brainwashed to kill the Prime Minister of Malaysia. His friends disappear, his father is disappointed in him, and he feels that he's not good as a model anymore. Zoolander soon befriends former rival and fellow male model Hansel (Owen Wilson) and journalist Matilda (Christine Taylor). Can Zoolander and his new friends find out how to prevent the incident before it's too late?