The movie was filmed on location in Brazil and along the Amazon River immediately after production of the previous film, "Tarzan and the Great River."
All three of Mike Henry's Tarzan films were completed before the first ("Tarzan and the Valley of Gold") was released in 1966.
The roles of opposing brothers Nagambi and Buhara were played by real life brothers Rafer and Ed Johnson.
Citing exhaustion and unsafe work conditions, Mike Henry bowed out of the Tarzan television series and sued Sy Weintraub's Banner Productions. The case was settled for an undisclosed sum. Ron Ely replaced him as Tarzan.